What would happen to the predominant protonation state and charge of the his and asp side chains if the ph were to change from 7.40 to 5.00?

Answers

Answer 1

The predominant protonation state and charge of the His and Asp side chain will be predominantly protonated and positively charged if both its p[tex]K_{a}[/tex] values is more than 5.

We know that,

pH = p[tex]K_{a}[/tex] + ( log [ [tex]A^{-1}[/tex] ] / [ HA ] )

where,

[ [tex]A^{-1}[/tex] ] represents deprotonated form

[ HA ] represents protonated form

Consider pH = p[tex]K_{a}[/tex]

In this case,

[ [tex]A^{-1}[/tex] ] / [ HA ] = 1

This means that protonated and deprotonated forms are equal.

This also means that as pH decreases, the acid's state will be predominantly protonated and its charge will be positive.

The relationship between pH and p[tex]K_{a}[/tex] shown above is known as Henderson-Hasselbach equation

Therefore, the predominant protonation state and charge of the His and Asp side chain will be predominantly protonated and positively charged if both its p[tex]K_{a}[/tex] values is more than 5.

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Related Questions

Can and object have a negative position and a positive velocity? Or vice versa, a positive position and a negative velocity? Explain your reasoning, do not just give a simple sentence answer.​

Answers

Imagine a ball is moving on the following horizontal line.

. . . . . . . . . . . . . . . . . . . O. . . . . . . . . . . . . . . . . .

Take right as positive. O is the starting point of the ball. Denote the ball by o.

. . . . . . . . . . . . . . . . . . . O. . . . . . . ... . . o . . . . . .

Assume the ball is moving to the right. It has positive displacement since it is on the right of O, and positive velocity since its positive displacement is increasing.



. . . . . . . . . . . . . . . . . . . O. . . . o . . . . . . . . . . . . .

Now the ball is returning to O. It still has positive displacement since its current position is still on the right of O. However, its velocity is negative since its positive displacement is decreasing and the direction of the velocity vector points left, which is the negative side.

By now you should be able to come up with a scenario where the ball has negative displacement and positive velocity.

You can observe the same phenomenon in daily life. Say, as a stretched spring bounces to its starting position, if we let the returning direction be positive, the string has negative displacement since it is on the negative direction, but has positive velocity. Bungee jump can also used to illustrate the phenomenon.

The force that accelerates a rocket in outer space is exerted on the rocket by the?

Answers

Gases at pressure are released by rockets as they travel towards space. According to Newton's third law, the combustion chamber's exhaust gases push the rocket with an accelerating force known as the thrust.

Explain exactly Newton's Third Law:

According to Newton's third law, if an object A pulls on an object B, then object B must exert an equal-sized and opposite-direction force on the first thing directed in the opposite direction. This law illustrates a symmetry in nature whereby forces always occur in pairs and whereby no body can exert a force without also being subjected to one.

What are Newton's 3rd law examples?

Action and response are always equal but always move in the opposite direction, according to Newton's third law of motion. A human walking on the ground, a hammer driving a nail, a magnet attracting a paper clip, and a horse pulling a cart are all examples of Newton's third rule of motion.

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A battery is discharging. electric current exits the battery through the ______ terminal, at a ______ potential than when it entered

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When a battery discharges the current exits through the positive terminal at a higher potential than it entered.

When a battery discharges the current exits the battery through the positive terminal as a circuit connected to that should conduct current from positive to a negative potential.Accordingly, the current enters the battery at its negative terminal.In practicality, batteries contain some internal resistance that restricts the current flow during current flow.That is why there is a potential difference between the 2 terminals.To drive the current through the external circuit connected to the battery, it keeps a higher potential at its positive terminal while the negative terminal is kept at a lower potential in contrast.

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A plane lands on a runway with a speed of 115 m/s, moving east, and it slows to a stop in 11.0 s. what is the magnitude and direction of the plane's average acceleration during this time interval?

Answers

By using uniform motion, the acceleration of plane is - 10.45 m/s² .

We need to know about the uniform motion to solve this problem. The uniform motion is the motion of an object which has acceleration applied. It can be determined as

vt = vo + a . t

vt² = vo² + 2a . s

s = vo . t + 1/2 . a . t²

where vt is final velocity, vo is initial velocity, a is acceleration, t is time interval and s is displacement.

From the question above, we know that:

vi = 115 m/s

vt = 0

t = 11 s

By using first equation, we can calculate the acceleration

vt = vo + a . t

0 = 115 + a . 11

11a = -115

a = - 10.45 m/s²

Hence, the acceleration of plane is - 10.45 m/s² .

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A schematic can tell an electrician that the switches are normally
until the sensor senses smoke.
a. locked
b. open
c. closed
d. charged

Answers

The correct answer is Option B) Open.

A schematic can tell an electrician that the switches are normally open

until the sensor senses smoke.

What is a schematic diagram?

A simple, understandable graphical representation of a plan or model is called a schematic diagram. Simple lines and symbols are used in schematics to convey details like what, how, and where. A schematic diagram's primary role is to highlight circuit components and the relationships between them. Schematics are a very useful tool for troubleshooting since they show which parts are connected in series or parallel and how.

An example of an electrical switch is one that is normally open. A typically open switch remains "off" when it is not compressed. The inside electrical connections are to blame for this. In a typically open switch, the contacts are open when the switch is off. This indicates that the switch is "off" because the electrical connection is damaged.

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Distance versus time is plotted and a best-fit line is found to be y = 0.098 x 0.01y=0.098x 0.01. what are the units of the slope 0.098?

Answers

The unit of the slope is m/s

Given that y = 0.098x + 0.01

According to slope formula, y = mx + c

Slope, m = 0.098

Slope of the line is equal to the velocity of the object in a distance-time graph. Unit of velocity is m/s.

Therefore, the unit of the slope is m/s

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River water held behind a dam is a form of ________. group of answer choices
a. potential energy
b. chemical energy
c. thermodynamics
d. kinetic energy

Answers

Potential energy is present in the river water behind a dam.

How is potential energy defined?Potential energy is a form of stored energy that is dependent on the relationship between different system components. When a spring is compressed or stretched, its potential energy increases. If a steel ball is raised above the ground as opposed to falling to the ground, it has more potential energy.The object's mass, its mass in relation to some reference points, and the gravitational field it is in all affect the potential energy of the object.Joule is the SI unit of potential energy as a result (J)As weight and height increase, gravitational potential energy rises.

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On hoods where sashes open vertically, work with the hood sash in the _____ position

Answers

On hoods where sashes open vertically, work with the hood sash in the lowest position.

What Is A Sash On A Fume Hood?

In the event of a fire, the fume hood sash offers a containment space. It functions as a blast barrier. The sash itself, together with the bypass grill above the sash, controls the fume hood's airflow properties. The sash's position does regulate the air velocity traveling through the fume hood, even if it has no effect on the amount of air passing through the fume hood. Air velocity is another element that affects chemical vapor capture. Raising the sash reduces the capture velocity, allowing vapors to start flowing over the sill and into the room's air.

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8. Determine the density of a cube that has a mass of 40.5g and a volume of 9cm3 .

Answers

Answer:

d = 2.70 g/mL

Explanation:

search the next one up on go ogle it will give you an answer i promise

A point on a standing wave that is always stationary is a(n) _____. antinode maximum minimum node

Answers

A point on a standing wave that is always stationary is an antinode.

What is antinode?

An antinode is the location where constructive interference of the incoming and reflected waves creates the maximum amplitude of the wave.

Antinodes are points on a stationary wave that oscillate with maximum amplitude.

Nodes are points of zero amplitude and appear to be fixed.

Thus, a point on a standing wave that is always stationary is an antinode.

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Your weight is:__________
a. actually your mass.
b. the gravitational attraction between you and the earth.
c. a property of mechanical equilibrium.
d. the same in all locations.

Answers

Your body weight is the gravitational attraction between you and the Earth.

What is gravity?

Gravity, which means "weight" in Latin, is a basic interaction in physics that causes all objects with mass or energy to attract one another. The electromagnetic force, the weak interaction, and the strong interaction are all significantly stronger than gravity, which is by far the weakest of the four fundamental interactions. As a result, it has no appreciable impact on subatomic particle level phenomena. On Earth, gravity imparts weight to tangible items, and the Moon's gravity creates tides in the oceans. However, gravity is the most important interaction between objects at the macroscopic scale, determining the motion of planets, stars, galaxies, and even light.

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The full moon is opposite the sun in the sky, and rises as the sun sets. what is the approximate angular separation of the sun and the full moon?

Answers

The approximate angular separation of the sun and the full moon is 180°

The full moon is opposite the sun in the sky, and rises as the sun sets is may be understand as ,the Moon can be seen in the day light  sky at any phase except for the new moon, when it's invisible to us, and full moon, when it's below the horizon during the day. The crescent through quarter phases are high in the sky during the day, but the daytime gibbous phases can be glimpsed only just before the Sun sets

In the crescent  phase, the lit-up part of the Moon increases from 0.1% to 49.9%. is growing, while crescent refers to the curved sickle shape.

The gibbous moon is the phase of moon in that appears more than half lighted but less than full.

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Assuming that the relationship between spring compression and height is quadratic, how far will the ball go at the highest setting, which compresses the spring 3 cm ?

Answers

Assuming that the relationship between spring compression and height is quadratic, 2.25m far will the ball go at the highest setting,  compresses the spring 3 cm

How do you calculate a compression spring's solid height?

The solid height, h1, of an unground spring is (n+1)d, where n is the number of coils and d is the wire diameter (including platings and coating) in inches. The height, h2, of ground but not squared springs is (n-1)d. The solid height, h3, of ground and squared springs is (n-0.75)d

When a spring is compressed, the potential energy is stored in the mechanical bonds between atoms, which may be thought of as little springs. The spring as a whole cannot decompress until it breaks, but little portions may when they fall off. The majority of the stored energy is used to decompress each little component.

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What is the magnitude and direction of the magnetic flux density b within the air?

Answers

Magnetic flux density - It is the force acting per unit current per unit length on a wire placed to magnetic field at right angle.

It is denoted by B

unit of B is tesla (T)

                 

The total no. of magnetic field lines passing through a area is called magnetic flux.

Magnitude of the magnetic flux - It is equal to the area of the surface and having perpendicular direction to the plane of the surface.

Its unit is weber (Wb)

Direction to the magnetic flux density - The direction is north pole to the south pole.

The magnetic field lines are known as lines of magnetic flux.

flux lines are not in direction of force but perpendicular.

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How deep under the surface of a lake would the pressure be double that at the surface?

Answers

Answer:

approx  33 ft

Explanation:

 One atmosphere of pressure is added per 33 ft of depth

For motion along a straight line it ______ possible for speed to be constant while acceleration is not zero.

Answers

For motion along a straight line it NOT possible for speed to be constant while acceleration is not zero.

If the acceleration is not zero means that the speed has changed whether to higher (positive acceleration) or lower (negative acceleration) if the object is slowing down.

When the speed is constant, it means that the velocity at the beginning of the motion and the velocity at the ending of the motion are the same.

What is acceleration?

It is a physical quantity that indicates the variation of velocity as a function of time, it is expressed in units of distance per time squared e.g.: m/sec2 ; km/h2

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an asteroid is 180,000km away from the moon on a collision course. how much time will it take before the asteroid is 10km away if it is moving at a constant velocity of 36,000m/s?

Answers

Answer:

See below

Explanation:

(180 000 - 10) km  /  36 km/s = 4999.7 =~ 5000 seconds = 83 .3 min

The ball in front of you is going to drop one meter. how long will it take to fall?

Answers

The ball will take 0.45 seconds to reach the ground

How will we solve this question?

We will use Newton’s laws of motion, so

H= [tex](1/2)gt^2[/tex] taking height= 1m

[tex]1= (1/2) x 9.8 x t^2[/tex]

[tex]t=\sqrt{10/49} = 0.45 seconds[/tex]

What are the three laws of motion given by Newton?

The 3 laws of motion given by Newton are as follows:

1) Unless an unbalanced force acts upon it, an item at rest remains at rest, and an object in motion continues to move in a straight line at a constant pace.

2) An object's acceleration is influenced by its mass and the force being applied.

3) Whenever one thing applies force to another, the second object applies the opposing, equal force to the first.

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A resistor carries 0.40 a when connected to a 9.0-v battery. what is theresistance of the resistor?

Answers

The resistance of the resistor which carries 0.40 a when connected to a 9.0-v battery is 22.5 ohm

Given:

current of resistor = 0.40 A

voltage of resistor = 9.0 V

To Find:

the resistance of the resistor

Solution: Resistance of a resistor with current I and voltage V is defined as the ability of the element to resist the flow of current through it. It's SI unit is V/A or ohm. Ohms () are used to express resistance values. Electricity will flow from high to low when two terminals have an electron difference. That flow is countered by resistance. The current decreases as resistance increases. Conversely, the higher the current, the lower the resistance.

Voltage = Current x Resistance

Resistance = Voltage/Current

Resistance = 9 V/0.40 A = 22.5 ohm

Hence, the resistance of the resistor is 22.5 ohm

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What is the acceleration of a 10 kg mass pushed 5 n forceushed by a 5n(kg-m/s2) (use gresa method)

Answers

The final acceleration of the object is 2 m/[tex]s^{2}[/tex].

In this problem,

Applied force(F) = 10 N

The object’s mass (m) is 5 kg.

Having said that,

An object’s force is equal to the product of its mass and the acceleration it experiences as a result of the applied force.

i.e., Mass + Acceleration = Force (a)

F= m×a

Therefore,

A= F÷m

A= (10÷5) m/sec²

A= 2 m/sec²

Consequently, the object’s acceleration,

A=2 m/sec²

Concept of force and acceleration:

This states that the rate of velocity change of an object is directly proportional to the applied force and moves in the direction of the applied force.

It can be expressed mathematically as force (N) = mass (kg) x acceleration (m/s2). Therefore, an object with constant mass will accelerate in direct proportion to the applied force.

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A car is traveling at a speed of 33 m/s . (a) what is its speed in kilometers per hour? (b) is it exceeding the 90 km/h speed limit?

Answers

According to the statement:

a) speed is equal to 118 km/h in kilometres per hour.

b) yes it is exceeding 90km/h.

What does speed mean?

The pace at which an object's position changes in any direction is referred to as speed. Speed is defined as the ratio of something like the distance traversed to the time required to cover that distance. . . Speed is a scalar quantity since it just has a direction and no magnitude..

How are the speeds determined?

Speed is determined by dividing the distance by the time. Calculating the units for speed requires knowledge of the units for both time and distance.. The units in this example will be meters per second (m/s), since the distance is measured in meters (m) and the time is measured in seconds (s).

(a)s₂= 118.km/h is its speed in kilometres per hour.

1h = 3600s

1km = 1000m

s₂= (33m/s) *[tex]\left(\frac{60 \times 60}{1000}\right)[/tex]

= 118.8km/h

s₂= 118.km/h

(b) yes it is exceeding 90km/h.

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How much did chevron pay in cash dividends to common shareholders during the first nine months of 2013? please provide your answer in millions without comma separator or decimal (ex: 343323456)

Answers

The correct answer for chevron pay in cash dividends to common shareholders during the first nine months of 2013 is 5572144100 dollors .

The dividend paid by Chevron foe 9 months of 2013 is $ 5572 millions.

Calculation:

No. Of outstanding shares = 1,921,429,000

Dividend per share = $2.9

Dividend paid = No. of outstanding shares * dividend per share

= 1,921,429,000 * 2.9

= $5,572,144,100

A dividend is a payment made to shareholders in exchange for their investment in a company's equity, and it is usually derived from the company's net profits. When a cash dividend is paid, the funds are transferred to a liability account known as dividends payable.

When the company makes the payment on the dividend payment date, which is usually a few weeks after the ex-dividend date, this liability is removed. Cash dividends and tick dividends have no effect on a company's net income or profit.

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When a retailer offers t-shirts in small, medium, large, and x-large, and in 25 colors, the competitive strategy they are using is?

Answers

When a retailer offers t-shirts in small, medium, large, and x-large, and in 25 colors, the competitive strategy they are using is Variety

What is competitive strategy ?

A business uses a set of rules and practises known as a competitive strategy to acquire a competitive edge in the market. It is the procedure for choosing and carrying out strategies that enable a company to strengthen its position in the market.

This plan was developed after evaluating the opportunities, threats, strengths, and weaknesses of the opposition and contrasting them with your own.

Establishing a competitive advantage in the market is the goal of a competitive strategy. Porter's Five Forces Model is the main instrument for assessing an organization's competitive position in the market.

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The fact that the lunar phases repeat on the same solar dates about every 19 years (the metonic cycle) can be used to __

Answers

The Metonic cycle is a period of almost exactly 19 years after which the lunar phases recur at the same time of the year.

The Metonic cycle is defined as ,235 synodic months is just 2 hours, 4 minutes and 58 seconds longer than 19 tropical years.

In Athens, at 5th century BC, give the cycle to be a whole number of days, 6,940. Using these whole numbers facilitates the construction of a lunisolar calendar.

A tropical year is longer than 12 lunar months and shorter than 13 of them. The arithmetic representation of  12×12 + 7×13 = 235 allows it to be seen that a combination of 12 "short" years (12 months) and 7 "long" years (13 months) will be almost  equal to 19 solar years.

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What would the ratio of deprotonated to protonated histidines be if the phph decreased to 6.40?

Answers

The ratio of deprotonated to protonated histidines is [tex]10^{6.4 - pK_{a} }[/tex] : 1

We know that,

pH = p[tex]K_{a}[/tex] + ( log [ [tex]A^{-1}[/tex] ] / [ HA ] )

where,

[ [tex]A^{-1}[/tex] ] represents deprotonated form

[ HA ] represents protonated form

Given that,

pH = 6.4

pH = p[tex]K_{a}[/tex] + ( log [ [tex]A^{-1}[/tex] ] / [ HA ] )

6.4 = p[tex]K_{a}[/tex] + ( log [ [tex]A^{-1}[/tex] ] / [ HA ] )

[ [tex]A^{-1}[/tex] ] / [ HA ] = [tex]10^{6.4 - pK_{a} }[/tex]

The relationship between pH and p[tex]K_{a}[/tex] shown above is known as Henderson-Hasselbach equation

Therefore, the ratio of deprotonated to protonated histidines is [tex]10^{6.4 - pK_{a} }[/tex] : 1

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The energy driving the global water cycle is provided by:________
a. rotation of the earth on its axis.
b. solar energy.
c. wind.
d. tides.

Answers

The energy driving the global water cycle is provided by solar energy.

What is a solar energy?

Solar energy is the term for solar radiation, which has the ability to ignite chemical reactions, produce heat, or create electricity. The total solar energy incident on Earth far exceeds both the present and future energy needs of the planet. This highly diffused source might potentially provide all of the energy required in the future if properly harnessed. Due to its limitless supply and lack of environmental impact compared to the finite fossil fuels coal, petroleum, and natural gas, solar energy is predicted to gain popularity as a renewable energy source in the twenty-first century. Although the Sun is a very potent energy source and sunlight is by far the most abundant energy that Earth receives, the intensity of sunlight at the planet's surface is actually rather low.

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The mass of the mars exploration rover is 1,063 kg. the gravity on mars is about 0.38 that of earth.1)where would the normal force exerted on the rover when it rests on the surface of the planet be greater?

Answers

The normal force exerted on the rover when it rests on the surface of the planet be greater is 3,125.22 N.

What is normal force?

A normal force is defined as the force that a surface exerts on an object.

N = W

N = mg

where;

m is mass of the objectg is acceleration due to gravity

Normal force is proportional to the weight of an object be considered.

Normal force of the rover

N = mg

N = 1,063 kg x 0.3(9.8 m/s²)

N = 3,125.22 N

Thus, the normal force exerted on the rover when it rests on the surface of the planet be greater is 3,125.22 N.

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If an electron is detached from an atom, the atom is converted to a positive ion called a(n):________

Answers

If an electron is detached from an atom, the atom is converted to a positive ion called a(n): Cation

Cations are positively charged ions formed when neutral atoms lose electrons. Chemical elements that are cations include:

Alkali metals that lose an electron and form a cation with 1+ charge.The alkali metals of the earth, which lose 2 electrons and form 2+ cation.Aluminum, which loses 3 electrons to form 3+ cation.

What is an atom?

The atom is the smallest part of the composition of matter, it is indivisible and is composed of a nucleus that has protons and neutrons, and around the nucleus there are the electrons.

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The body process in which an adequate supply of oxygen converts glucose into energy is called:________

Answers

Aerobic metabolism can occur both aerobically (using oxygen), or anaerobically (without oxygen). During aerobic cellular respiration, glucose reacts with oxygen, forming ATP that can be used by the cell.

What is Cellular respiration ?

Through the process of cellular respiration, organisms mix oxygen with food molecules, directing the chemical energy contained in these substances toward life-sustaining processes while excreting carbon dioxide and water as waste.

Glycolysis, also known as the citric acid cycle, is the first stage of cellular respiration. The Krebs cycle, also known as the electron transport chain, is the second stage

Anaerobic and aerobic respiration are the two basic forms of cellular respiration. It need oxygen (O2) to make ATP during an exclusive type of cellular respiration known as aerobic respiration.

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The assumption that the earth moved about the sun in a circle is known as the ___________ model.

Answers

Answer:

heliocentrism, a cosmological model in which the Sun is assumed to lie at or near a central point (e.g., of the solar system or of the universe) while the Earth and other bodies revolve around it.

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Evaluate the peripheral blood smear. what is the tonicity of the plasma (extracellular fluid)? how to conclude a debate Two numbers have these properties.Both numbers are greater than 6.Their highest common factor (HCF) is 6.Their lowest common multiple (LCM) is 60.Find the two numbers, writing your answers on one line in the form,The two numbers are ... and .+ Use additive inverses and their properties to find the equivalent expressions You need to write a program that has karel move 6 times and then put a ball. Which control structure do you need to use? Simplify : p^2-p-12/p^2-10p+24 What command can be used to remove partitions and convert a drive to gpt? group of answer choices Find the volume of the solid. please help me with this math homework Which polymers are composed of amino acids? nucleic acids carbohydrates proteins monomers II Two electrons are in the vicinity of a proton. The potential energy of theproton is-1.6 x 10-25 J. (a) What is the potential at the proton's position? (b) If one ofthe electrons is 1.0 cm from the proton, what is the distance of the secondelectron from the proton?Please explain HOW to answer this(especially part B) Those who favor abortion on demand and increased taxation of the rich are more likely than others to be:_______ Who forced King John to sign the Magna Carta?A. Monks in English monasteriesOB. English noblesOC. English peasantsO D. A group of French knights Which bits of a mips m.l. instruction are used to identify the operation to be performed? A management process in which people in different parts of an organization share information throughout the development of a product or process is called _______. When the concentration of a substance differs from one area to another, this creates a concentration. 11. A proton is uniformly accelerated from rest to 80.0% of the speed of light in18 hours, 6 minutes, 45 seconds. What is the acceleration of the proton? Starting from rest and moving in a straight line, a runner achieves a velocity of 14 m/s in 10 seconds. what is the average acceleration of the runner? The competitive environment that most marketing managers experience in developed economies is:_______ can someone answer this quickly.